Disruption of mitochondrial electron transport chain function potentiates the pro-apoptotic effects of MAPK inhibition

The mitochondrial network is a major site of ATP production through the coupled integration of the electron transport chain (ETC) with oxidative phosphorylation In melanoma arising from the V600E mutation in the kinase v-RAF murine sarcoma viral oncogene homolog B (BRAF V600E), oncogenic signaling enhances glucose-dependent metabolism while reducing mitochondrial ATP production Likewise

Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3

Background: Overexpression of survivin is associated with resistance to radiotherapy and poor survival in many cancer types However, in squamous cells carcinoma of head and neck (SCCHN), previous studies have revealed diverging results regarding survivin s role in clinical outcome In this study, we aim to 1) evaluate the clinical significance of survivin expression in SCCHN; 2)

Overcoming resistance to cetuximab with honokiol, a small-molecule polyphenol

Overexpression and activation of the Epidermal Growth Factor Receptor (EGFR) have been linked to poor prognosis in several human cancers Cetuximab is a monoclonal antibody against EGFR, that is used for the treatment in head and neck squamous cell carcinoma (HNSCC) and metastatic colorectal cancer Unfortunately, most tumors have intrinsic or acquire resistance to cetuximab during the course of therapy

Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice

Doxorubicin is the chemotherapeutic drug of choice for a wide variety of cancers, and cardiotoxicity is one of the major side effects of doxorubicin treatment One of the main cellular targets of doxorubicin in the heart is mitochondria Mitochondrial sirtuin, SIRT3 has been shown to protect against doxorubicin-induced cardiotoxicity